Open Access<p>Overexpression of IGFBP5 Enhances Radiosensitivity Through PI3K-AKT Pathway in Prostate Cancer</p>
Author(s) -
Xue Chen,
Yu Qi,
Hailun Pan,
Ping Li,
Xufei Wang,
Shihua Fu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s257701
Subject(s) - prostate cancer , du145 , pi3k/akt/mtor pathway , radiosensitivity , cancer research , protein kinase b , medicine , gene knockdown , cancer , radiation therapy , prostate , biology , oncology , signal transduction , cell culture , lncap , microbiology and biotechnology , genetics
Radiotherapy is the main treatment for localized prostate cancer. The therapeutic effects of radiotherapy are highly dependent on radiosensitivity of target tumors. Here, we investigated the impact of insulin-like growth factor-binding protein 5 (IGFBP5) on irradiation therapy in prostate cancer.