Open Access<p>Tumor-Associated CD163<sup>+</sup> M2 Macrophage Infiltration is Highly Associated with PD-L1 Expression in Cervical Cancer</p>
Author(s) -
Fan Guo,
Yilong Feng,
Gang Zhao,
Ran Zhang,
Zhiyong Cheng,
Weina Kong,
Huili Wu,
Bin Xu,
Xiang Lv,
Xiumin Ma
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s257692
Subject(s) - cd163 , cd68 , immunohistochemistry , tumor microenvironment , medicine , tumor infiltrating lymphocytes , pd l1 , infiltration (hvac) , cancer research , pathology , macrophage , cancer , biology , immunotherapy , in vitro , biochemistry , physics , thermodynamics
Programmed death-ligand 1 (PD-L1) is a negative costimulatory molecule, and its main function is widely considered to be in the regulation of T cells. Tumor-associated macrophages (TAMs) are an important part of the tumor microenvironment, and they also play an important role in immunosuppression. However, the relationship between the expression of PD-L1 and TAMs in cervical carcinoma (CC) remains unclear. We detected the expression of PD-L1 and TAMs in tumor tissue to study the correlation between them.