Open Access<p>Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis</p>
Author(s) -
Shihao You,
Xianghui He,
Mei Wang,
Lina Mao,
Lu Zhang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s256347
Subject(s) - glioma , viability assay , in vivo , gene knockdown , cell migration , cell growth , chemistry , cancer research , gene silencing , in vitro , cyclin d1 , mtt assay , downregulation and upregulation , blot , cell , pharmacology , microbiology and biotechnology , cell cycle , biology , apoptosis , biochemistry , gene
Tanshinone IIA (TIIA) is one of the active constituents derived from the rhizome of Danshen, a traditional Chinese herbal. Recently, microRNAs (miRNAs) have been suggested to be associated with the anticancer role of TIIA. However, it remains vague of the interaction between miRNAs and TIIA in glioma, a common aggressive brain tumor in humans.