Open Access<p>Overexpression of Rab40b Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway</p>
Author(s) -
Liwei Shi,
Zhibo Zhang,
Li Zhong,
Jian Gao,
Jianping Gong,
Hang Chen,
Ming Yu,
Yiyin Zhang,
Zhi Li
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s255870
Subject(s) - cancer research , cell growth , cyclin d1 , pi3k/akt/mtor pathway , mmp2 , cell cycle , protein kinase b , metastasis , cyclin e1 , biology , cell , signal transduction , cancer , microbiology and biotechnology , genetics
Rab40b is an evolutionarily conserved Rab GTPase that plays an important role in intracellular trafficking and is closely related to cancer progression. However, the role and potential molecular mechanism of Rab40b in hepatocellular carcinoma (HCC) have not yet been elucidated.