Open Access<p>Digital Image Analysis of CD8+ and CD3+ Tumor-Infiltrating Lymphocytes in Tongue Squamous Cell Carcinoma</p>
Author(s) -
YenLin Huang,
Chieh Yu Lin,
HuangKai Kao,
ShaoYu Hung,
Hung-Ju Ko,
YuChen Huang,
YuCheng Chang,
KaiPing Chang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s255816
Subject(s) - medicine , tongue , tumor infiltrating lymphocytes , perineural invasion , cd8 , univariate analysis , oncology , hazard ratio , multivariate analysis , confidence interval , gastroenterology , pathology , cancer , immunotherapy , immune system , immunology
The presence of CD8+ tumor-infiltrating lymphocytes (TILs) has been reported to be associated with treatment outcomes in many types of solid tumors. However, the results vary due to the various methods of visual estimation and subjective interpretation. The current study is the first to use digital image analyses to evaluate the density of CD8+/CD3+ TILs in tongue squamous cell carcinoma (TSCC).