Open Access<p>Blocking circ_0013912 Suppressed Cell Growth, Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells in vitro and in vivo Partially Through Sponging miR-7-5p</p>
Author(s) -
Weisheng Guo,
Lin Zhao,
Guangya Wei,
Peng Liu,
Yu Zhang,
Liran Fu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s255808
Subject(s) - in vivo , pancreatic ductal adenocarcinoma , blocking (statistics) , in vitro , cancer research , cell growth , chemistry , microbiology and biotechnology , medicine , biology , pancreatic cancer , cancer , computer science , biochemistry , computer network
Circular RNAs have been emerging as biomarkers in diagnosis and prognosis of pancreatic ductal adenocarcinoma (PDAC). The hsa_circ_0013912 (circ_0013912) has been retrieved to be upregulated in PDAC. Here, we further investigated its role in PDAC cells, as well as its mechanism via serving as competing endogenous RNA (ceRNA) for miRNA (miR)-7-5p, which is abundant in pancreas and suppresses the development of PDAC.