Open Access<p>MicroRNA-421 Inhibits Apoptosis by Downregulating Caspase-3 in Human Colorectal Cancer</p>
Author(s) -
Yifan Zhou,
Xuejun Cheng,
Yufeng Wan,
Tingting Chen,
Qing Zhou,
Zhengguang Wang,
Huaqing Zhu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s255787
Subject(s) - apoptosis , microrna , dna fragmentation , cancer research , tunel assay , caspase 3 , caspase 7 , microbiology and biotechnology , downregulation and upregulation , antagomir , transfection , biology , colorectal cancer , reporter gene , chemistry , cell culture , cancer , gene expression , programmed cell death , gene , genetics
Dysregulated microRNAs (miRNAs/miRs) have been reported to play significant roles in pathogenesis of colorectal cancer (CRC). Previous studies have demonstrated that miR-421 regulates apoptosis in some cancers. Caspase-3 plays a key role in apoptosis, but the relationship between miR-421 and caspase-3 in CRC has not been determined. In this study, we investigated the role of miR-421 in CRC and the relationship between miR-421 and caspase-3.