Open Access<p>Exosomal CircGDI2 Suppresses Oral Squamous Cell Carcinoma Progression Through the Regulation of MiR-424-5p/SCAI Axis</p>
Author(s) -
Yu Zhang,
Kaiqi Tang,
Lizhu Chen,
Min Du,
Zhipeng Qu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s255687
Subject(s) - microvesicles , cell growth , cancer research , exosome , microrna , cell , biology , western blot , cell migration , microbiology and biotechnology , cell culture , chemistry , biochemistry , gene , genetics
Exosomes are small membrane vesicles that are secreted by most cell types. Circular RNAs (circRNAs) have recently been identified in exosomes, and exosomal circRNAs exert important biological activities in human cancers, including oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate whether circRNA GDP dissociation inhibitor 2 (circGDI2) was transferred by exosomes and how exosomal circGDI2 regulated OSCC cell malignant behaviors.