Open Access<p>Discovery of Ebselen as an Inhibitor of 6PGD for Suppressing Tumor Growth</p>
Author(s) -
Feng Qi,
Xiuru Li,
Wenjing Sun,
Yubo Li,
Yu Yuan,
Baozhang Guan,
Shuai Zhang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s254853
Subject(s) - ebselen , cell growth , carcinogenesis , cancer research , cancer , cancer cell , cell cycle , biology , enzyme , chemistry , pharmacology , medicine , biochemistry , glutathione , glutathione peroxidase
The 6-phosphogluconate dehydrogenase (6PGD) was upregulated in many solid cancers and plays an important role in tumorigenesis. In the present study, we want to discover an old drug as an inhibitor of 6PGD for suppressing tumor growth.