Open Access<p>Paeonol Inhibits Cell Proliferation, Migration and Invasion and Induces Apoptosis in Hepatocellular Carcinoma by Regulating miR-21-5p/KLF6 Axis</p>
Author(s) -
Miaoguo Cai,
Wei Shao,
Huijun Yu,
Hong Ye,
Lili Shi
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s254485
Subject(s) - viability assay , paeonol , cyclin d1 , apoptosis , cell growth , cancer research , cell migration , microbiology and biotechnology , western blot , mtt assay , cell cycle , mmp2 , biology , flow cytometry , cell , chemistry , medicine , pathology , downregulation and upregulation , biochemistry , genetics , alternative medicine , gene
Hepatocellular carcinoma (HCC) is one of the most common tumors with high mortality. MicroRNAs (miRNAs) were reported as crucial markers for the diagnosis of HCC. Paeonol exerted many pharmacological effects on tumor progression. This study aimed to elucidate the underlying molecular mechanism of paeonol in HCC progression.