Open Access<p>Silencing lncRNA AFAP1-AS1 Inhibits the Progression of Esophageal Squamous Cell Carcinoma Cells via Regulating the miR-498/VEGFA Axis</p>
Author(s) -
Wenhao Shen,
Lei Yu,
Aihua Cong,
Yang Song,
Peng Wang,
Gaohua Han,
Bin Gu,
Wei Zhang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s254302
Subject(s) - vascular endothelial growth factor a , gene silencing , cell growth , gene knockdown , flow cytometry , cancer research , apoptosis , microrna , cell migration , downregulation and upregulation , antisense rna , cell , biology , chemistry , microbiology and biotechnology , vascular endothelial growth factor , messenger rna , vegf receptors , gene , biochemistry , genetics
In view of the continuous increase of the mortality rate, esophageal squamous cell carcinoma (ESCC) develops into a major health concern. In this study, we aimed to investigate the underlying mechanism of long noncoding RNA (lncRNA) actin filament-associated protein 1 antisense RNA (AFAP1-AS1)/microRNA-498 (miR-498)/vascular endothelial growth factor A (VEGFA) in ESCC cells.