Open Access<p>Prospective Study of the Clinical Impact of Epithelial and Mesenchymal Circulating Tumor Cells in Localized Prostate Cancer</p>
Author(s) -
Hailong Liu,
Jie Ding,
Yanyuan Wu,
Di Wu,
Jun Qi
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s253997
Subject(s) - prostate cancer , circulating tumor cell , medicine , clinical significance , receiver operating characteristic , logistic regression , oncology , stepwise regression , stage (stratigraphy) , prostate , cancer , population , biomarker , pathology , metastasis , biology , paleontology , biochemistry , environmental health
Although circulating tumor cells (CTCs) are considered as a surrogate marker in monitoring disease progression and treatment response in late stage prostate cancer (PCa), its clinical impact in localized PCa remains unclear, indicating the limitation that is simply based on cell count. This perspective observational study aimed to detect the epithelial-to-mesenchymal transition (EMT) subtypes of CTCs in localized PCa and analyze their clinical relevance and application in predicting PCa stages before surgery compared with the Partin table.