Open Access<p>Circular RNA hsa_circ_0003496 Contributes to Tumorigenesis and Chemoresistance in Osteosarcoma Through Targeting (microRNA) miR-370/Krüppel-Like Factor 12 Axis</p>
Author(s) -
Chaofan Xie,
Guanzhao Liang,
Yinfeng Xu,
Erhu Lin
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s253969
Subject(s) - carcinogenesis , gene knockdown , cancer research , cell growth , microrna , apoptosis , chemistry , osteosarcoma , western blot , flow cytometry , microbiology and biotechnology , downregulation and upregulation , biology , gene , biochemistry
Osteosarcoma (OS) is the most common primary malignancy of bone with a high incidence in children. Circular RNAs (circRNAs) play crucial roles in the carcinogenesis and chemoresistance of OS. In the current work, we focused on the function and mechanism of hsa_circ_0003496 (circ_0003496) in OS progression and chemoresistance.