Open Access<p>Targeting EGFR Enriches Stem Cell-Like Properties in Salivary Adenoid Cystic Carcinoma by Activating the Notch1 Pathway</p>
Author(s) -
Yan Wang,
Han Ye,
Shengming Xu,
Ling Zhang,
Xiangkai Zhang,
Jiong Deng,
Weimin Ye,
Shuli Liu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s253500
Subject(s) - erlotinib , cancer research , cancer stem cell , epidermal growth factor receptor , stem cell , egfr inhibitors , biology , adenoid cystic carcinoma , cancer , medicine , carcinoma , microbiology and biotechnology
Salivary adenoid cystic carcinoma (SACC), a rare cancer arising in the salivary glands, is characterized by high rates of relapse and distant metastasis. Epidermal growth factor receptor (EGFR) has been implicated in SACC carcinogenesis. However, prospective trials of EGFR-targeting therapies in SACC are limited, and the optimum regimen is unclear.