Open Access<p>Expression Pattern and Prognostic Utility of PME-1 in Patients with Hepatocellular Carcinoma</p>
Author(s) -
Benni Du,
Hongfeng Liao,
Sheng Zhang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s252873
Subject(s) - hepatocellular carcinoma , medicine , proportional hazards model , immunohistochemistry , oncology , survival analysis , pathological , univariate analysis , multivariate analysis , cancer , log rank test , pathology , gastroenterology
Hepatocellular carcinoma (HCC) remains one of the most common malignancies. While there is lack of markers capable of predicting which patients are at risk of aggressive course of the disease. Although a few protein phosphatase methyl-esterase-1 (PME-1) tumor-promoting mechanisms have been reported, the role of PME-1 in cancer including HCC occurrence and progression remains to be elucidated. The aim of this study was to explore the expression pattern and relationship between PME-1 with the pathological parameters in patients with HCC.