Open Access<p>Aurora-B Promotes Osteosarcoma Cell Growth and Metastasis Through Activation of the NPM1/ERK/NF-κβ/MMPs Axis</p>
Author(s) -
Honghai Song,
Yang Zhou,
Ai-Fen Peng,
Jiaming Liu,
Xin Wu,
Wenzhao Chen,
Zhili Liu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s252847
Subject(s) - mapk/erk pathway , cancer research , cell growth , apoptosis , western blot , phosphorylation , osteosarcoma , chemistry , metastasis , microbiology and biotechnology , biology , medicine , cancer , biochemistry , gene
Osteosarcoma (OS) is the most common primary malignant tumor of the bone in young adolescents and children. We explored the underlying mechanism of Aurora-B in promoting OS cell proliferation and metastasis.