Open Access<p>KLHL22 Regulates the EMT and Proliferation in Colorectal Cancer Cells in Part via the Wnt/β-Catenin Signaling Pathway</p>
Author(s) -
Yi Song,
Huiping Yuan,
Jia Wang,
Yuhe Wu,
Yuhong Xiao,
Shengxun Mao
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s252232
Subject(s) - wnt signaling pathway , cancer research , cell growth , catenin , carcinogenesis , epithelial–mesenchymal transition , colorectal cancer , lrp6 , pi3k/akt/mtor pathway , signal transduction , blot , biology , cancer , microbiology and biotechnology , metastasis , genetics , gene
Colorectal cancer (CRC) is one of the most common aggressive malignancies. KLHL22 functions as a tumor suppressor, and previous findings have demonstrated that KLHL22 can regulate the development of breast cancer and CRC. However, few studies have investigated the role of KLHL22 in CRC cell epithelial-to-mesenchymal transition (EMT) and proliferation. The current study aimed to detect the role of KLHL22 in CRC cell proliferation and EMT and to elucidate the probable molecular mechanisms through which KLHL22 is involved with these processes.