Open Access<p>Blocking circ_0000520 Suppressed Breast Cancer Cell Growth, Migration and Invasion Partially via miR-1296/SP1 Axis Both in vitro and in vivo</p>
Author(s) -
Huidong Zang,
Yuhui Li,
Xue Zhang,
Guomin Huang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s251666
Subject(s) - competing endogenous rna , cell growth , gene knockdown , downregulation and upregulation , carcinogenesis , gene silencing , cancer research , microrna , flow cytometry , chemistry , cell , microbiology and biotechnology , apoptosis , biology , cancer , long non coding rna , gene , biochemistry , genetics
Breast cancer (BCa) is an overwhelming malignant tumor mainly in women globally. Circular RNAs (circRNAs) are a special type of noncoding RNAs involved in competing endogenous RNA (ceRNA) network, a classic molecular mechanism of the tumorigenesis of human cancers, including BCa. Here, we intended to explore the role and mechanism of hsa_circ_0000520 ( circ_0000520 ) in BCa cells.