Open Access<p>SOX10 – A Novel Marker for the Differential Diagnosis of Breast Metaplastic Squamous Cell Carcinoma</p>
Author(s) -
Jialin Qi,
Zhi Hu,
Heng Xiao,
Ruijie Liu,
Wei Guo,
Zhi-Chun Yang,
Kewen Ma,
Shitong Su,
Ping Tang,
Xunjian Zhou,
Jianhua Zhou,
Kuansong Wang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s250867
Subject(s) - differential diagnosis , medicine , sox10 , pathology , metastasis , immunohistochemistry , gata3 , lung , cancer , cancer research , biology , embryo , biochemistry , neural crest , gene , transcription factor , microbiology and biotechnology
Differential diagnosis of metaplastic squamous cell carcinoma of breast (MSCCB) is difficult. In particular, in terms of metastatic MSCCB, because of the low speciality of traditional markers such as mammaglobin, gross cystic disease fluid protein-15 (GCDFP-15) and GATA binding protein 3 (GATA3), the most common problem is differentiating the spread of MSCCB to the lung from a primary lung squamous cell carcinoma. It is urgently required to explore a novel marker to aid in differential diagnosis.