Open Access<p>Effect of Chitosan Magnetic Nanoparticles Loaded with Ang2-siRNA Plasmids on the Growth of Melanoma Xenografts in Nude Mice</p>
Author(s) -
Xiuying Shan,
Wenjun Yu,
Xuejun Ni,
Tingting Xu,
Lei Chen,
Zhaoliang Liu,
Xuefeng Hu,
Yanding Zhang,
Beichen Cai,
Biao Wang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s250479
Subject(s) - apoptosis , tunel assay , melanoma , immunohistochemistry , angiogenesis , cancer research , in vivo , chemistry , cell growth , microbiology and biotechnology , biology , pathology , medicine , biochemistry
Angiopoietin-2 (Ang-2) has been proven to be a potential agent for malignant cancer treatment. The aim of the current study was to investigate the inhibitory effects of chitosan magnetic nanoparticles (CMNPs) loaded with Ang-2 small interfering RNA (Ang2-siRNA) plasmids (Ang2-CMNPs) on malignant melanoma.