Open Access<p>MiRNA-128 and MiRNA-142 Regulate Tumorigenesis and EMT in Oral Squamous Cell Carcinoma Through HOXA10</p>
Author(s) -
Yao Yao,
Qian Xu,
Liyong Yan,
Yan Jiao,
Qingqi Su,
Xiaoguang Li,
Cong Liu,
Feng Zhao
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s250093
Subject(s) - microrna , vimentin , carcinogenesis , cancer research , flow cytometry , epithelial–mesenchymal transition , apoptosis , cell growth , gene knockdown , chemistry , downregulation and upregulation , microbiology and biotechnology , biology , cancer , immunology , gene , immunohistochemistry , biochemistry , genetics
Oral squamous cell carcinoma (OSCC) accounts for more than 90% of all oral cavity cancers, and the 5-year survival rate for OSCC patients remains unsatisfactory. MiRNA-128/miRNA-142 has been reported to work as a tumor suppressor in diverse tumors. However, the biological function of miR-128/miR-142 in OSCC is still unknown.