Open Access<p>SPOCK1 Involvement in Epithelial-to-Mesenchymal Transition: A New Target in Cancer Therapy?</p>
Author(s) -
Li Sun,
Si Yu Li,
Qiu Shi Guo,
Wei Zhou,
Hongmei Zhang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s249754
Subject(s) - epithelial–mesenchymal transition , metastasis , cancer research , cancer , biology , wnt signaling pathway , carcinogenesis , cancer cell , pi3k/akt/mtor pathway , microbiology and biotechnology , signal transduction , genetics
Cancer metastasis is the main obstacle to increasing the lifespan of cancer patients. Epithelial-to-mesenchymal transition (EMT) plays a significant role in oncogenic processes, including tumor invasion, intravasation, and micrometastasis formation, and is especially critical for cancer invasion and metastasis. The extracellular matrix (ECM) plays a crucial role in the occurrence of EMT corresponding to the change in adhesion between cells and matrices.