Open Access<p>CFTR Functions as a Tumor Suppressor and Is Regulated by DNA Methylation in Colorectal Cancer</p>
Author(s) -
Can Liu,
Chao Song,
Jiaxi Li,
Qing Sun
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s248539
Subject(s) - methylation , dna methylation , cancer research , cystic fibrosis transmembrane conductance regulator , colorectal cancer , microbiology and biotechnology , cell growth , biology , cancer , gene expression , cystic fibrosis , gene , genetics
Cystic fibrosis transmembrane conductance regulator (CFTR) was shown to be downregulated or silenced in carcinomas and acts as a candidate tumor suppressor gene. However, the function of CFTR gene in colorectal cancer (CRC) is still unclear. This aim of this study was to investigate the CFTR promoter methylation status and its impact on the expression and functional role of CFTR in CRC development.