Open Access<p>Psoralen Suppresses Cisplatin-Mediated Resistance and Induces Apoptosis of Gastric Adenocarcinoma by Disruption of the miR196a-HOXB7-HER2 Axis</p>
Author(s) -
Lei Jin,
Xuemei Ma,
Tingting Wang,
Yang Yang,
Nan Zhang,
Na Zeng,
Zhigang Bai,
Jie Yin,
Jun Zhang,
Guoqian Ding,
Zhong-Tao Zhang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s248094
Subject(s) - cisplatin , downregulation and upregulation , psoralen , apoptosis , cyclin d1 , cancer research , chemistry , cyclin e1 , medicine , biology , chemotherapy , cell cycle , biochemistry , gene , dna
The present study aimed to investigate the impact of psoralen on miR-196a-5p expression and function, and to reveal the mechanism underlying miR-196a-5p-mediated inhibition and the reversal of cisplatin (DDP) resistance.