Open Access<p>Evaluation of Concordance Between Deficient Mismatch Repair and Microsatellite Instability Testing and Their Association with Clinicopathological Features in Colorectal Cancer</p>
Author(s) -
Hao Bai,
Rong Wang,
Wei Cheng,
Yifan Shen,
Haijun Li,
Wei Xia,
Zhenglin Ding,
Yuhong Zhang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s248069
Subject(s) - microsatellite instability , concordance , colorectal cancer , dna mismatch repair , medicine , pms2 , immunohistochemistry , oncology , lynch syndrome , cancer , pathology , microsatellite , biology , gene , genetics , allele
Microsatellite instability (MSI) is one of the most important molecular characteristics of colorectal cancer (CRC), which mainly results from defective DNA mismatch repair (MMR). This study was performed to investigate the concordance between deficient MMR and MSI testing, and to evaluate the association of these two results with clinicopathological characteristics in Chinese CRC patients.