Open Access<p>Identification of High-Frequency Methylation Sites in RNF180 Promoter Region Affecting Expression and Their Relationship with Prognosis of Gastric Cancer</p>
Author(s) -
Fang Han,
Shuang Liu,
Jingjing Jing,
Hao Li,
Yuan Yuan,
Liping Sun
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s246995
Subject(s) - methylation , identification (biology) , promoter , cancer , cancer research , dna methylation , biology , microbiology and biotechnology , medicine , oncology , genetics , gene expression , gene , botany
Ring finger protein 180 (RNF180) is a tumor suppressor gene regulated by promoter methylation. We previously demonstrated that the RNF180 promoter methylation could be a risk factor for gastric cancer (GC); and eight high-frequency hypermethylated CpG sites were associated with GC. However, it is not clear whether these key sites can affect gene expression and involve in prognosis. The aim of this study was to investigate the effects of above CpG sites on the gene expression and prognosis of GC.