Open Access<p>Gene Therapy with Cytosine Deaminase and Endostatin Fusion Gene Mediated by Endothelial Progenitor Cells in Hepatomas</p>
Author(s) -
Yuelin Zhang,
Tianyu Zhou,
Jing Ai,
Sheng-Qun Chen,
Feng Chen,
ChunHui Nie,
Xinhua Chen,
Gengui Zhou,
Hongliang Wang,
Tian Zhu,
Baoquan Wang,
ZiNiu Yu,
Jing Li,
Liming Wu,
Shusen Zheng,
JunHui Sun
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s245998
Subject(s) - cytosine deaminase , endostatin , progenitor cell , genetic enhancement , fusion gene , cancer research , transfection , apoptosis , microbiology and biotechnology , cd31 , medicine , biology , immunology , stem cell , gene , angiogenesis , biochemistry
Gene-targeting therapy provides a novel therapeutic approach for tumor treatment using genetically modified endothelial progenitor cells (EPCs) as cellular carriers. This study applied EPCs armed with cytosine deaminase (CD) and endostatin (ES) fusion gene in liver cancer to explore its therapeutic effect.