Open Access<p>15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity</p>
Author(s) -
Yaling Li,
Junjie Li,
Juanjuan Dong,
Lei Zhang,
Dongling Liu,
Jianzheng He,
Yali She,
Chengxu Ma,
Yongqi Liu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s245726
Subject(s) - carcinogenesis , foxp3 , hazard ratio , malignancy , cancer research , cancer , immunohistochemistry , proportional hazards model , metastasis , medicine , biology , oncology , immunology , immune system , confidence interval
Host immunity plays a vital role in tumorigenesis, including in tumor invasion and metastasis. However, the precise underlying mechanism remains to be explored. The enzyme 15-PGDH, which plays a key role in prostaglandin degradation, is a critical inflammatory mediator in gastric cancer (GC) tumorigenesis.