Open Access<p>Upregulation of METTL3 Expression Predicts Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma</p>
Author(s) -
Tian-Liang Xia,
Shumei Yan,
Yuan Li,
MuSheng Zeng
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s245019
Subject(s) - immunohistochemistry , downregulation and upregulation , medicine , proportional hazards model , esophageal squamous cell carcinoma , biomarker , esophageal cancer , oncology , hazard ratio , messenger rna , carcinoma , cancer research , cancer , pathology , biology , gene , confidence interval , biochemistry
The N 6 -methyladenosine (m 6 A) RNA modification of mRNA mediates various cellular functions and cancer progression. However, the roles of m 6 A RNA modification in the regulation of esophageal squamous cell carcinoma (ESCC), the dominant subtype of esophageal cancer in Asia, were unclear.