Open Access<p>Functions and Clinical Significance of UPF3a Expression in Human Colorectal Cancer</p>
Author(s) -
Xuguang Bao,
Yuji Huang,
Weimin Xu,
Guanglei Xiong
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s244486
Subject(s) - colorectal cancer , immunohistochemistry , gene knockdown , clinical significance , metastasis , cancer research , cancer , medicine , oncology , univariate analysis , tissue microarray , biology , stage (stratigraphy) , survival analysis , multivariate analysis , gene , genetics , paleontology
Nonsense-mediated mRNA decay (NMD) can degrade mRNAs with a premature termination codon (PTC), and undegraded mRNAs with PTC mutations can induce a genetic compensation response (GCR) by upregulating its compensatory genes. UPF3a refers to up-frame shift 3A (UPF3a) participating in NMD pathway and GCR. It inhibits the NMD pathway while it stimulates GCR. Notably, the role of UPF3a in cancer remains unclear.