Open Access<p>Fucoidan Induces Apoptosis and Inhibits Proliferation of Hepatocellular Carcinoma via the p38 MAPK/ERK and PI3K/Akt Signal Pathways</p>
Author(s) -
Yifei Duan,
Jingjing Li,
Jing Xue,
Xiaobo Ding,
Yang Yu,
Qingxi Zhao
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s243495
Subject(s) - mapk/erk pathway , protein kinase b , pi3k/akt/mtor pathway , hepatocellular carcinoma , signal pathway , p38 mitogen activated protein kinases , cancer research , apoptosis , fucoidan , hepatic carcinoma , chemistry , microbiology and biotechnology , signal transduction , medicine , biology , biochemistry , polysaccharide
Fucoidan is a natural bioactive product with broad therapeutic applications. Hepatocellular carcinoma (HCC) is a common malignancy of the liver associated with a relatively high mortality rate; thus, effective treatments are urgently needed. Here, the effects of fucoidan on HCC and the underlying mechanism were explored.