Open Access<p>Biliverdin Reductase A (BLVRA) Promotes Colorectal Cancer Cell Progression by Activating the Wnt/β-Catenin Signaling Pathway</p>
Author(s) -
Haiyan Mao,
Yuan Xu,
Zhengrong Zhang,
Guo-Zhuang Sun,
Wei Zhu,
Dawei Qiao,
Xudong Yin,
Siping Liu,
Bo Peng
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s242531
Subject(s) - biliverdin reductase , wnt signaling pathway , cancer research , blot , cell growth , apoptosis , gene knockdown , colorectal cancer , flow cytometry , vimentin , biology , cancer , microbiology and biotechnology , immunohistochemistry , signal transduction , immunology , heme oxygenase , enzyme , biochemistry , gene , heme , genetics
Biliverdin reductase A (BLVRA) is a pleiotropic enzyme that converts biliverdin-IX-alpha into the antioxidant and anti-nitrosative compound, bilirubin-IX-alpha. It is related to various diseases, including cancer. It is overexpressed in many types of cancers and promotes cancer development and metastasis, but the effects of BLVRA in colorectal cancer have not been researched at present. This study was aimed to investigate the effects of biliverdin reductase A (BLVRA) in vivo and vitro experiments and its possible mechanism.