Open Access<p>MALAT1 Promotes Cell Tumorigenicity Through Regulating miR-515-5p/EEF2 Axis in Non-Small Cell Lung Cancer</p>
Author(s) -
Ru Feng,
Liang Liu,
Can Zou,
Jing Zeng,
Yasheng Xu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s242425
Subject(s) - malat1 , gene knockdown , cancer research , apoptosis , cell growth , viability assay , microbiology and biotechnology , adenocarcinoma , biology , microrna , mtt assay , carcinogenesis , flow cytometry , chemistry , cancer , rna , long non coding rna , gene , biochemistry , genetics
Previous studies suggested long noncoding RNA metastasis associated with lung adenocarcinoma transcript 1 (lncRNA MALAT1) acted as a tumor promoter to promote cell carcinogenesis in non-small cell lung cancer (NSCLC). MALAT1 was found to exist in serum exosomes of several cancers. However, the role of exosomal-derived MALAT1 in NSCLC remains poorly understood.