Open Access<p>Exosomal Transfer of lncRNA H19 Promotes Erlotinib Resistance in Non-Small Cell Lung Cancer via miR-615-3p/ATG7 Axis</p>
Author(s) -
Rongtao Pan,
Haiyan Zhou
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s241095
Subject(s) - erlotinib , cancer research , chemistry , cell growth , gene knockdown , viability assay , downregulation and upregulation , exosome , mtt assay , western blot , transfection , cell culture , cell , microbiology and biotechnology , microvesicles , biology , microrna , epidermal growth factor receptor , biochemistry , receptor , genetics , gene
Drug resistance restrains the effect of drug therapy in non-small cell lung cancer (NSCLC). However, the mechanism of the acquisition of drug resistance remains largely unknown. This study aims to investigate the effect of exosomal lncRNA H19 on erlotinib resistance in NSCLC and the underlying mechanism.