Open Access<p>TOP2A Promotes Cell Migration, Invasion and Epithelial–Mesenchymal Transition in Cervical Cancer via Activating the PI3K/AKT Signaling</p>
Author(s) -
Wang Bi,
Yulong Shen,
Zheng Yin,
Zhengjun Qi,
Guijia Huang,
Xia Shan,
Rui Gao,
Fenghu Li,
Zhi Huang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s240577
Subject(s) - hela , epithelial–mesenchymal transition , pi3k/akt/mtor pathway , cancer research , protein kinase b , cell migration , cell , cervical cancer , chemistry , ly294002 , cell growth , cancer cell , cancer , biology , signal transduction , microbiology and biotechnology , medicine , metastasis , biochemistry
Topoisomerases type IIA (TOP2A) was identified to present with a high-expression pattern in cervical cancer. However, TOP2A role in the progression of cervical cancer remains unknown. Here, we aimed to explore the effect and reveal the underlying mechanism of TOP2A in the migration, invasion and epithelial-mesenchymal transition (EMT) of cervical cancer.