Open Access<p>Sal-Like Protein 4 Transcription Factor: A Significant Diagnostic Biomarker Involved in Childhood ALL Resistance and Relapse</p>
Author(s) -
Farzaneh Ohadi,
Soheila Rahgozar,
Elaheh Sadat Ghodousi
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s240469
Subject(s) - minimal residual disease , transcription factor , medicine , stem cell , biomarker , cancer research , haematopoiesis , bone marrow , oncology , reverse transcription polymerase chain reaction , leukemia , biology , immunology , gene , gene expression , genetics
Sal-like protein 4 transcription factor ( SALL4 ) is a stem cell transcription factor that plays an essential role in the maintenance and self-renewal of embryonic and hematopoietic stem cells, functioning as an oncogene in several cancers. However, the role of SALL4 in the biological behavior of childhood acute lymphoblastic leukemia and its relationship with multidrug resistance and relapse has remained largely unknown.