Open Access<p>Alteration in Expression of miR-32 and FBXW7 Tumor Suppressor in Plasma Samples of Patients with T-cell Acute Lymphoblastic Leukemia</p>
Author(s) -
Sanaz Mansouri,
Behzad Khansarinejad,
Ghasem Mosayebi,
Aziz Eghbali,
Mahdieh Mondanizadeh
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s238470
Subject(s) - oncomir , microrna , leukemia , lymphoblastic leukemia , biology , t cell leukemia , cancer research , haematopoiesis , suppressor , apoptosis , cell , t cell , microbiology and biotechnology , immunology , gene , stem cell , immune system , genetics
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and malignant neoplasm that arises from the hematopoietic T-cell precursors. Inactivation of FBXW7 gene is frequently observed in T-cell acute lymphoblastic leukemia, suggesting a significant tumor-suppressive role for FBXW7 in the pathobiology of this leukemia. Considering the role of microRNAs in cell proliferation and regulation of apoptosis, the aim of this study was to identify novel oncogenic microRNAs that suppress FBXW7 in patients with T-ALL.