Open Access<p>WD Repeat Domain 5 Promotes Invasion, Metastasis and Tumor Growth in Glioma Through Up-Regulated Zinc Finger E-Box Binding Homeobox 1 Expression</p>
Author(s) -
Bin Dai,
Zhiyong Xiao,
Guangtong Zhu,
Beibei Mao,
Hui Huang,
Feng Guan,
Zhenyang Lin,
Weicheng Peng,
Xin Liang,
Bo-Lun Zhang,
Zhiqiang Hu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s237582
Subject(s) - gene knockdown , glioma , cancer research , biology , metastasis , zinc finger , cell migration , cell growth , homeobox , cell culture , transcription factor , cancer , gene , genetics
Glioma is one of the important diseases that threaten human survival in today's society. WD repeat domain 5 (WDR5) belongs to the components of the lysine methyltransferase complex. WDR5 is involved in gene transcription regulation, cell senescence, cancer and other biological events through methylation modification. However, its expression and function in glioma are still unclear.