Open Access<p><em>S1PR2</em> Knockdown Promotes Migration and Invasion in Multiple Myeloma Cells via NF-κB Activation</p>
Author(s) -
Meng Pang,
Chunyuan Li,
Dong Zheng,
Ying Wang,
Jing Wang,
Weilong Zhang,
Fang Li,
Hongmei Jing
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s237330
Subject(s) - gene knockdown , downregulation and upregulation , cancer research , small hairpin rna , cell migration , small interfering rna , biology , cell , microbiology and biotechnology , cell culture , chemistry , transfection , gene , biochemistry , genetics
The presence of circulating plasma cells (cPCs) was associated with a worse prognosis in multiple myeloma patients. However, the underlying mechanisms involved in the migration and invasion of bone marrow myeloma cells (BMMCs) to cPCs remains unclear. Here, we investigate the possible factors related to hematogenous myeloma cell dissemination and potential regulatory mechanisms.