Open Access<p>Active Monomer RTR-1 Derived from the Root of <em>Rhodomyrtus tomentosa</em> Induces Apoptosis in Gastric Carcinoma Cells by Inducing ER Stress and Inhibiting the STAT3 Signaling Pathway</p>
Author(s) -
Xiangqiang Zhang,
Jinxia Cheng,
Peiyan He,
Jinyan Zhu,
Zhixian Chen,
Shenyu Miao,
GuoCai Wang,
Jianwei Jiang,
Yuechun Wang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s237201
Subject(s) - apoptosis , cell cycle , mtt assay , cell cycle checkpoint , flow cytometry , cell growth , chemistry , cancer cell , blot , microbiology and biotechnology , biology , biochemistry , cancer , genetics , gene
Rhodomyrtus tomentosa , a flowering plant from the Myrtaceae family, is considered an antitumour substance with versatile biological and pharmacological activities. RTR-1 is an active monomer purified from the root of Rhodomyrtus tomentosa . However, the detail of mechanism involving in RTR-1 anti-cancer activity remains to be elucidated, and the effect on gastric cancer cells is unknown.