Open Access<p>A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma</p>
Author(s) -
Zhongjing Lv,
Kun Wu,
Xing Qin,
Jian Yuan,
Ming Yan,
Jianjun Zhang,
Lizhen Wang,
Tong Ji,
Wei Cao,
Wantao Chen
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s236266
Subject(s) - head and neck squamous cell carcinoma , cancer research , gene silencing , oncology , biology , medicine , cancer , head and neck cancer , biochemistry , gene
In our previous study, serine protease inhibitor Kazal-type 5 (SPINK5), which encodes the product of serine protease inhibitor lymphoepithelial Kazal-type-related inhibitor (LEKTI) was found to be down-regulated in head and neck squamous cell carcinoma (HNSCC) using oligonucleotide microarrays. However, the function and clinical implications of SPINK5/LEKTI remain obscure in HNSCC.