Open Access<p>circPCNX and Pecanex Promote Hepatocellular Carcinoma Cell Viability by Inhibiting miR-506</p>
Author(s) -
Peng Sun,
Xinyi Fan,
Xiao Hu,
Xiaoyue Fu,
Wei Qian,
Yunjin Zang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s232940
Subject(s) - hepatocellular carcinoma , viability assay , competing endogenous rna , cancer research , long non coding rna , western blot , apoptosis , circular rna , biology , downregulation and upregulation , luciferase , microrna , cell growth , rna , transfection , cell culture , gene , biochemistry , genetics
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers, while the molecular mechanism is not clear. Circular RNAs (circRNAs) are a class of naturally occurring endogenous noncoding RNAs that prove to play important roles in the occurrence, development and prognosis of HCC. In this study, we focused on an abnormally expressed circular RNA-circPCNX in HCC and study the function of circPCNX and Pecanex (PCNX) in HCC.