Open Access<p>4E-BP1<sup>Thr46</sup> Phosphorylation Association with Poor Prognosis in Quantitative Phosphoproteomics of Portal Vein Tumor Thrombus Revealed that 4E-BP1Thr46 Phosphorylation is Associated with Poor Prognosis in HCC</p>
Author(s) -
Xincong Lin,
Yao Huang,
Ying Sun,
Xionghong Tan,
Jiahe Ouyang,
Bixing Zhao,
Yingchao Wang,
Xiaohua Xing,
Jingfeng Liu
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s230849
Subject(s) - phosphorylation , hepatocellular carcinoma , phosphoproteomics , metastasis , biomarker , cancer research , medicine , phosphoprotein , protein phosphorylation , oncology , pathology , biology , cancer , biochemistry , protein kinase a
Early formation of portal vein tumor thrombosis (PVTT) is a key characteristic of hepatocellular carcinoma (HCC) metastasis, but to date, the aetiology of PVTT in HCC metastasis is largely unknown. We aim to find highly sensitive and specific biomarkers for the prediction of HCC prognosis.