Open Access<p>MicroRNA-146a as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma</p>
Author(s) -
Maryam Sadegh Shesh Poli,
Safoura Khajeniazi,
Nasser Behnampour,
Mohamad Reza Kalani,
Abdolvahab Moradi,
Abdoljalal Marjani
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s229397
Subject(s) - biomarker , proportional hazards model , microrna , medicine , hazard ratio , receiver operating characteristic , carcinogenesis , oncology , esophageal squamous cell carcinoma , cancer , cancer research , pathology , biology , gene , confidence interval , biochemistry
MicroRNAs including miR146a have a regulatory role on the expression of genes and act with binding to 3'-UTR region of the genes. Cyclooxygenase-2 (COX-2) is involved in carcinogenesis as an inflammatory marker, and microRNA-146a (miR-146a) as a negative regulatory factor. We aimed to evaluate miR146a expression as a prognostic or diagnostic biomarker for esophageal squamous cell carcinoma (ESCC) and also an association between miR146a and COX2 expression.