Open Access<p>Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling</p>
Author(s) -
Fubiao Ni,
Hengjie Tang,
Cheng Wang,
Hewei Zhang,
Chenlei Zheng,
Ning Zhang,
Bicheng Chen,
Lu Sun
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s228926
Subject(s) - pancreatic cancer , apoptosis , cancer research , p70 s6 kinase 1 , pi3k/akt/mtor pathway , cancer , cancer cell , biology , chemistry , medicine , biochemistry
Although the incidence of pancreatic cancer has increased markedly, the 5-year survival rate for this disease is considerably low compared with other types of cancer. Moreover, the mortality rate of pancreatic cancer is similar to its incidence rate. Current therapeutic agents exhibit a lack of specificity for pancreatic cancer. Baohuoside I is traditionally used to treat orgasmic disorder and inflammation. However, its role in pancreatic cancer is unknown.