Open Access<p>Allylated Curcumin Analog CA6 Inhibits TrxR1 and Leads to ROS-Dependent Apoptotic Cell Death in Gastric Cancer Through Akt-FoxO3a</p>
Author(s) -
Vinothkumar Rajamanickam,
Tao Yan,
Liangrong Wu,
Yu Zhao,
Xiaohong Xu,
Heping Zhu,
Xi Chen,
Meihong Wang,
Zhoudi Liu,
Zhiguo Liu,
Guang Liang,
Yi Wang
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s227415
Subject(s) - curcumin , cancer , protein kinase b , apoptosis , thioredoxin reductase , cancer research , cancer cell , chemistry , reactive oxygen species , cytotoxicity , microbiology and biotechnology , oxidative stress , biology , medicine , thioredoxin , biochemistry , in vitro
Gastric cancer is one of the leading causes of cancer-related deaths. Allylated monocarbonyl analogs of curcumin (MACs) have been reported to selectively inhibit a broad range of human cancers including gastric cancer. However, the precise molecular mechanisms underlying the inhibitory activities of MACs are not fully known.