Open Access<p>Oncogenic Roles Of A Histone Methyltransferase SETDB2 In AML1-ETO Positive AML</p>
Author(s) -
Guangfu Mu,
Fangping Chen
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s227036
Subject(s) - methyltransferase , histone methyltransferase , cancer research , chemistry , histone , medicine , biology , methylation , genetics , gene
AML1-ETO produced by t(8;21) abnomality has multiple effects on the leukemogenesis of acute myeloid leukemia (AML). SET domain, bifurcated 2 (SETDB2) can mediate gene silencing by trimethylation of the ninth lysine residue of histone H3 protein (H3K9) of the promoter and has been confirmed as an oncogene in many cancers. The role of SETDB2 in AML1-ETO positive AML is not clear.