Open Access<p>AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer</p>
Author(s) -
Fei Xu,
Yun Xu,
Ji Xiong,
Jinghui Zhang,
Jian Wu,
Jie Luo,
Jianping Xiong
Publication year - 2020
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s225229
Subject(s) - protein kinase b , gene knockdown , cancer research , pi3k/akt/mtor pathway , cyclin d1 , cancer , epithelial–mesenchymal transition , oncogene , apoptosis , cancer cell , chemistry , biology , signal transduction , microbiology and biotechnology , cell cycle , metastasis , biochemistry , genetics
AOC1 is a copper-containing amine oxidase that is responsible for catalyzing the deamination of polyamines, which produces reactive oxygen species. Previous studies have demonstrated that polyamines are involved in the regulation of proliferation, migration, and apoptosis of cells. However, very little is known about the functions and regulatory mechanisms of AOC1 in tumors.