Open Access<p>Downregulation of Proline Hydroxylase 2 and Upregulation of Hypoxia-Inducible Factor 1α are Associated with Endometrial Cancer Aggressiveness</p>
Author(s) -
Chengcheng Zhu,
Huafeng Ding,
Junwen Yang,
Youwen Zhou,
Yang Luo,
Suhua Shi,
Ying Zhang,
Yalan Wei,
Guantai Ni
Publication year - 2019
Publication title -
cancer management and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.024
H-Index - 40
ISSN - 1179-1322
DOI - 10.2147/cmar.s223421
Subject(s) - downregulation and upregulation , endometrial cancer , western blot , immunohistochemistry , carcinogenesis , obstetrics and gynaecology , endometrium , medicine , hypoxia (environmental) , gynecology , andrology , cancer , biology , chemistry , gene , pregnancy , biochemistry , organic chemistry , oxygen , genetics
Proline hydroxylase 2 (PHD2) is involved in tumorigenesis. This study aimed to examine PHD2 and hypoxia-inducible factor 1α (HIF-1α) expression in different endometrial tissues and explore the correlations between PHD2 and HIF-1α expression with clinicopathological characteristics of endometrial cancer.