Open Access<p>NSD2 Promotes Renal Cancer Progression Through Stimulating Akt/Erk Signaling</p>
Author(s) -
Xu Han,
Lianhua Piao,
Xiaojun Xu,
Fengbao Luo,
Zhiwei Liu,
Xiaozhou He
Publication year - 2020
Publication title -
cancer management and research
Language(s) - Uncategorized
Resource type - Journals
ISSN - 1179-1322
DOI - 10.2147/cmar.s222673
Subject(s) - clear cell renal cell carcinoma , cancer research , protein kinase b , gene silencing , cell growth , gene knockdown , flow cytometry , mapk/erk pathway , pi3k/akt/mtor pathway , apoptosis , biology , chemistry , signal transduction , microbiology and biotechnology , renal cell carcinoma , medicine , oncology , genetics , gene
Nuclear receptor suppressor of variegation, enhancer of zeste, and trithorax (SET) domain-containing 2 (NSD2), is a well-known histone lysine methyltransferase (HMTase). The aim of this study was to investigate the biological role of NSD2 in clear cell renal cell carcinoma (ccRCC).